Compositions of media used in dissolution testing

 In dissolution testing, the composition of media plays a critical role in simulating the physiological conditions under which a drug will dissolve and be absorbed in the body. The media typically includes the following components

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Aqueous Solutions: Water is the primary solvent used due to its similarity to body fluids. It can be used alone or with other components to mimic different body conditions.

Buffers: These are used to maintain a specific pH, replicating various environments within the gastrointestinal tract, such as acidic conditions in the stomach (pH 1-3) or neutral to slightly basic conditions in the intestines (pH 6-7.5).

Surfactants: Surfactants like sodium lauryl sulfate may be added to simulate the effect of bile salts in the gastrointestinal tract, especially for poorly soluble drugs.

Osmolarity Adjusters: Ingredients like sodium chloride can be added to adjust the osmolarity of the dissolution medium to more closely resemble physiological conditions.

Co-solvents: Alcohols or other organic solvents may be used to improve the solubility of certain drugs that are poorly soluble in water.

These components are carefully selected based on the drug's chemical properties and the intended site of absorption to provide accurate and reproducible results during dissolution testing.