Beta Lactamase Inhibitors

 Beta-Lactamase Inhibitors are compounds that inhibit the activity of beta-lactamase enzymes produced by certain bacteria, which otherwise degrade beta-lactam antibiotics like penicillins and cephalosporins, rendering them ineffective. These inhibitors restore the effectiveness of beta-lactam antibiotics by preventing the breakdown of their structure.

Examples of Beta-Lactamase Inhibitors:

1. Clavulanic acid – Often combined with amoxicillin (e.g., Augmentin).
2. Sulbactam – Typically paired with ampicillin.
3. Tazobactam – Used with piperacillin (e.g., Zosyn).
4. Avibactam – Commonly combined with ceftazidime.

These combinations are used to treat infections caused by beta-lactamase-producing bacteria, such as certain strains of Staphylococcus, Enterobacteriaceae, and Pseudomonas.